Active Immunization against Poliomyelitis in Monkeys

The expanded programme in immunization against measles and poliomyelitis, Iran's Experience.

Experiments on Active Immunization against Experimental Poliomyelitis

The results obtained in this investigation indicate that poliomyelitis virus treated with tannin, sodium ricinoleate, or formalin does not constitute a satisfactory immunizing agent in monkeys against the experimental disease.

Intradermal versus Subcutaneous Immunization of Monkeys against Poliomyelitis

1. The introduction of considerable amounts of living, active poliomyelitis virus into the skin and subcutaneous tissue of monkeys protects the animals against intracerebral inoculations of similar virus material. 2. The degree of protection conferred by intradermal is greater than by subcutaneous injection. 3. During intradermal and subcutaneous inoculations, no local or general pathological s...

Intradermal Immunization of Monkeys with One Set of Injections of Poliomyelitis Virus

1. By means of a single large dose of poliomyelitis virus, distributed at a number of intradermal sites, active immunity has been produced in Macacus rhesus monkeys, as shown by skin neutralization and intracisternal tests. 2. In the small series (four animals) of monkeys so treated, neither abortive nor paralytic signs of experimental poliomyelitis appeared.

An Investigation into the Significance of Hormonal Factors in Experimental Poliomyelitis

1. Adult rhesus monkeys possess frequently a greater resistance to experimental infection with poliomyelitis virus than young monkeys as indicated by the prolongation of the incubation period and the content of feeble neutralizing substances in the normal serum. 2. Virucidal substances can be demonstrated in the normal serum of subadult chimpanzees. 3. Immature monkeys prepared with glandular a...

Observations on the Immunological Relation of Poliomyelitis to Louping Ill

The results of the work presented in the present paper show that louping ill and poliomyelitis immunologically are not closely related. Although relatively few experiments were performed, the data obtained were sufficiently decisive for our purposes. Certainly nothing was found to indicate that one might be able to immunize human beings against poliomyelitis by the use of louping ill virus. In ...